Bionity.COM Newsletter No. 01/2010, 01/13/2010

New Products and Services

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Fast, Efficient and Competitive Pipetting with CyBi^®-SELMA
Semi-automatic 96-fold pipettor with minimal required space
Semi-automatic pipettor for easy and fast filling of microplates using an intuitive touchscreen. Applications like replication or serial dilution can be executed reproducibly and conveniently...

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CERTOMAT® CTplus - the ideal shaker for mammalian cell suspensions
The first specialized CO₂ incubation shaker
The CERTOMAT® CTplus is the first incubation shaker specifically designed for cultivation of mammalian cell suspensions. Temperature, CO₂ concentration and humidity are under stringent control and kept constant by advanced insulation and sealing....

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MVA 2.1 - A Supporting Tool in Method Validation
The Useful Software for an Efficient and Rational Validation of Analytical Methods
"Method Validation in Analytics - MVA" has been designed for the calculation of validation data based primarily on the guidelines of the International Conference on the Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH)...

http://www.bionity.com/products/e/58007/

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PCR Diagnostics of Sepsis and Infectious Diseases
Direct pathogen detection from whole blood
The CE-IVD marked, PCR-based sepsis test, SepsiTest^TM, includes all reagents necessary for preparation of DNA from whole blood and pathogen detection. By using broad-range PCR, SepsiTest^TM allows the detection of more than 345 bacterial and fungal pathogens within only 4 hours....

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Field-Flow-Fractionation, another method to separate difficult samples
Eclipse 3 AFFF System
The Eclipse 3 is a state-of-the-art separation system using the asymmetric flow Field Flow Fractionation (AFFF) technique. The Eclipse integrates easily with Wyatt's multi-angle light scattering (MALS) instruments...

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Biotech News

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Latest News from Biotechnology and Pharma from 12/16/2009 to 01/12/2010

New target discovered for treatment of cancer
01/12/2010 - Researchers at Karolinska Institutet have discovered a new way of blocking the formation of blood vessels and halting the growth of tumours in mice. A substance that exploits this mechanism could be d...
http://www.bionity.com/news/e/111658/

Alligator Bioscience´s ADC-1004 for treatment of ischemia reperfusion injury reduced myocardial infarct size
01/12/2010 - Alligator Bioscience announced positive results from its drug candidate ADC-1004 in a closed-chest porcine model of acute myocardial infarction (AMI). ADC-1004 was found to significantly reduce infarc...
http://www.bionity.com/news/e/111659/

t2cure Appoints Dr Petra Rueck and Susanne Knigge as Co-CEOs
01/12/2010 - t2cure GmbH announced that it has appointed Dr. Petra Rueck and Mrs. Susanne Knigge to Co-CEO’s, effective January 1, 2010. Dr. Manfred Ruediger has laid down his assignment as CEO and Managing Direct...
http://www.bionity.com/news/e/111657/

Paper strips can quickly detect toxin in drinking water
01/12/2010 - A strip of paper infused with carbon nanotubes can quickly and inexpensively detect a toxin produced by algae in drinking water.
Engineers at the University of Michigan led the development of the n...
http://www.bionity.com/news/e/111623/

Clavis Pharma receives US Orphan Drug Designation for CP-4126 to treat pancreatic cancer
01/12/2010 - Clavis Pharma announced that the US Food & Drug Administration (FDA) has granted orphan drug designation to CP-4126 for the treatment of pancreatic cancer. The designation follows the equivalent desi...
http://www.bionity.com/news/e/111600/

'Robotic Scientist' will run experiments too complex for humans
01/11/2010 - A "robotic scientist" that can automatically plan and execute experiments may soon provide new insights into the biology of addiction to drugs and alcohol. Further down the road, the artificial intell...
http://www.bionity.com/news/e/111597/

Ron Branning Joins Genzyme to Lead Global Product Quality
01/11/2010 - Genzyme Corporation announced that Ron Branning, a 30-plus year bio/pharmaceutical veteran specializing in the development of world-class drug and device quality monitoring systems and regulatory comp...
http://www.bionity.com/news/e/111599/

Cell phone exposure may protect against and reverse Alzheimer's disease
Florida Alzheimer's Disease Research Center study in mice indicates long-term exposure to cell phone signals may even boost normal memory
01/11/2010 - The millions of people who spend hours every day on a cell phone may have a new excuse for yakking. A surprising new study in mice provides the first evidence that long-term exposure to electromagneti...
http://www.bionity.com/news/e/111509/

Johns Hopkins researchers say vaccine appears to 'mop up' leukemia cells Gleevec leaves behind
01/11/2010 - Johns Hopkins Kimmel Cancer Center researchers say preliminary studies show that a vaccine made with leukemia cells may be able to reduce or eliminate the last remaining cancer cells in some chronic m...
http://www.bionity.com/news/e/111506/

Unraveling kidney cancer
Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma
01/11/2010 - In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumour type to be sequenced to date. Clea...
http://www.bionity.com/news/e/111507/

New virus is not linked to chronic fatigue syndrome, suggests UK research
01/08/2010 - New UK research, published in PLoS ONE , has not reproduced previous findings that suggested Chronic Fatigue Syndrome may be linked to a recently discovered virus. The authors of the study, from Imper...
http://www.bionity.com/news/e/111444/

Biofrontera: Detailed phase III results confirm superiority of BF-200 ALA over Metvix
01/08/2010 - Biofrontera AG announced that it has received detailed results of the phase III comparative study with BF-200 ALA and Metvix® for the treatment of actinic keratosis.
A total of 27 study centers in ...
http://www.bionity.com/news/e/111484/

CLC bio achieves massive growth in 2009 and closes year with 7-figure deal
01/08/2010 - CLC bio announced that their financial year 2009 was closed with a 7-figure US Dollar deal involving a multinational corporation working extensively with high-throughput sequencing data analysis on mu...
http://www.bionity.com/news/e/111488/

Protein linked to leukemia 'bookmarks' highly active genes during cell division
01/08/2010 - Each cell inherits genes from its parent as well as epigenetic information – what amounts to an instruction manual that specifies which genes should be activated or "expressed," when and to what level...
http://www.bionity.com/news/e/111445/

New Abbott Gene-Based Test for Colorectal Cancer Receives CE Mark
01/08/2010 - Abbott announced it has received CE Marking (Conformité Européene) in the European Union for a new molecular diagnostic test, Abbott RealTime mS9 Colorectal Cancer, a non-invasive DNA assay that detec...
http://www.bionity.com/news/e/111487/

Protein central to being male plays key role in wound healing
01/07/2010 - A molecular receptor pivotal to the action of male hormones such as testosterone also plays a crucial role in the body's ability to heal, report scientists in the Journal of Clinical Investigation. In...
http://www.bionity.com/news/e/111367/

Frost & Sullivan Finds that Government Support Will Open Up Lucrative Opportunities in the Russian Healthcare Markets
01/07/2010 - Despite uncertain economic environment, Russia still represents a promising healthcare market with strong potential for further growth. The growth will be primarily driven by strong governmental suppo...
http://www.bionity.com/news/e/111382/

Boston Scientific Announces Completion of Enrollment in Aneurysm Coiling Clinical Trial
01/07/2010 - Boston Scientific Corporation announced that it has completed enrollment in its MAPS(TM) clinical trial, which is studying the coiling of intracranial aneurysms. This prospective, randomized trial com...
http://www.bionity.com/news/e/111442/

OncoMethylome Sciences to Perform MGMT Testing in Roche Phase III Study of Avastin for Glioblastoma
OncoMethylome's Technology is being used in Roche Clinical Trial Program with Avastin
01/07/2010 - OncoMethylome Sciences announced that it has entered into an agreement with F. Hoffmann-La Roche Ltd., of Basel Switzerland, for MGMT gene promoter methylation testing in a Phase III clinical trial fo...
http://www.bionity.com/news/e/111392/

OncoGenex Announces that a Randomized, Investigator-Sponsored Phase 2 Study Evaluating OGX-427 has Received Grant Funding
01/07/2010 - OncoGenex Pharmaceuticals, Inc. announced that a randomized, controlled, investigator-sponsored Phase 2 clinical trial evaluating OGX-427 when administered as a monotherapy to patients with castrate r...
http://www.bionity.com/news/e/111443/

Common anti-inflammatory drug could help prevent skin cancers, Stanford researcher says
01/06/2010 - A widely-available anti-inflammatory prescription drug can reduce the risk of a common skin cancer in humans, according to a researcher at Stanford's School of Medicine. Although oral administration o...
http://www.bionity.com/news/e/111364/

RWE Power, BRAIN join forces in white biotech: co-operation on CO2 as raw material for new products
01/06/2010 - To convert carbon dioxide into microbial biomass or biomolecules: such is the goal of co-operative research agreed between RWE Power and BRAIN AG. The power generator and the biotech company want to e...
http://www.bionity.com/news/e/111346/

Biodegradable particles can bypass mucus, release drugs over time
01/06/2010 - Johns Hopkins University researchers have created biodegradable nanosized particles that can easily slip through the body's sticky and viscous mucus secretions to deliver a sustained-release medicatio...
http://www.bionity.com/news/e/111365/

A single atom controls motility required for bacterial infection
01/06/2010 - Bacteria can swim, propelling themselves through fluids using a whip-like extension called a flaggella. They can also walk, strolling along solid surfaces using little fibrous legs called pili. It is ...
http://www.bionity.com/news/e/111366/

Experimental drug shows promise against brain, prostate cancers
01/06/2010 - An experimental drug currently being tested against breast and lung cancer shows promise in fighting the brain cancer glioblastoma and prostate cancer, researchers at UT Southwestern Medical Center ha...
http://www.bionity.com/news/e/111362/

Unusual protein modification involved in muscular dystrophy, cancer
01/05/2010 - With the discovery of a new type of chemical modification on an important muscle protein, a University of Iowa study improves understanding of certain muscular dystrophies and could potentially lead t...
http://www.bionity.com/news/e/111360/

Novartis to acquire Corthera Inc. for USD 120 million
01/05/2010 - Novartis will gain exclusive worldwide rights to relaxin, a recombinant version of a naturally occurring human peptide, through the acquisition of the privately held US biopharmaceutical company Corth...
http://www.bionity.com/news/e/111295/

Intercell starts an additional efficacy trial for its patch-based investigational Travelers’ Diarrhea Vaccine System in Asia
Phase II pilot efficacy trial - placebo controlled field study to evaluate efficacy and enterotoxigenic E. coli (ETEC) incidence of vaccinated European travelers to India
01/05/2010 - Intercell AG announced the start of a Phase II study in India as part of its clinical development program for the investigational Travelers’ Diarrhea (TD) Vaccine system. This placebo controlled field...
http://www.bionity.com/news/e/111347/

to-BBB and Lundbeck to join forces on brain delivery of antibodies for CNS diseases
01/05/2010 - to-BBB and H. Lundbeck A/S are entering into a research collaboration to evaluate delivery of antibodies to the brain for Central Nervous System (CNS) diseases. This research could provide the backbon...
http://www.bionity.com/news/e/111294/

Pieris Appoints a New CEO
01/05/2010 - Pieris AG announced the appointment of Stephen S. Yoder as CEO with immediate effect. Mr. Yoder takes over the position from interim CEO and co-founder Claus Schalper, who will remain CFO. Mr. Yoder j...
http://www.bionity.com/news/e/111345/

African-American ancestry clarified
Genetic study traces African-Americans' ancestry from Africa and Europe
01/04/2010 - Researchers may now reliably use genetics data to tell a person's ancestry - what percent of an African-American's genome stems from Europe, for example, and what percent comes from Africa.
The tec...
http://www.bionity.com/news/e/111287/

Novexel to be acquired by AstraZeneca
01/04/2010 - Novexel announced that its shareholders have signed a definitive agreement whereby Novexel shall be acquired by AstraZeneca for a total cash consideration of up to $505 million, including contingent p...
http://www.bionity.com/news/e/111289/

Ablynx Demonstrates Proof-of-Concept by Biomarker For Its Anti-Thrombotic ALX-0081
01/04/2010 - Ablynx announced detailed results from the open label extension of the Phase Ib study of its anti-thrombotic, ALX-0081, in patients with stable angina undergoing percutaneous coronary intervention (PC...
http://www.bionity.com/news/e/111286/

Biovitrum Sells Obesity Program to AstraZeneca
12/23/2009 - Biovitrum AB announced that AstraZeneca has acquired all of Biovitrum’s rights to its leptin modulator program aimed at treating obesity. Biovitrum will receive from AstraZeneca an upfront payment of ...
http://www.bionity.com/news/e/111185/

Memory in neural circuits
12/23/2009 - Neuronal reactions to visual sensations are more complex than previously thought. Nerve impulses generated in reaction to a visual stimulus create a spatio-temporal pattern that also contains informat...
http://www.bionity.com/news/e/110874/

NicOx submits naproxcinod MAA to the EMEA
12/23/2009 - NicOx S.A. announced that a Marketing Authorization Application (MAA) for naproxcinod has been submitted to the European Medicines Agency (EMEA) through the centralized procedure, seeking approval fo...
http://www.bionity.com/news/e/111186/

DBV Technologies expands Scientific Advisory Board
12/23/2009 - DBV Technologies (DBV) announced the appointment of US-based food allergy and paediatric asthma specialist Professor Robert Zeiger to its Scientific Advisory Board. In joining the Scientific Advisory ...
http://www.bionity.com/news/e/111188/

Investigational dual orexin receptor antagonist almorexant meets primary endpoint in phase III study
Evidence for differentiation from traditional GABA-agonist zolpidem observed
12/23/2009 - Actelion Ltd announced that the first phase III study with almorexant (RESTORA 1) has met its primary endpoint, superiority of the dual orexin receptor antagonist almorexant compared to placebo on obj...
http://www.bionity.com/news/e/111181/

UR study reveals chemo's toxicity to brain, possible treatment
12/22/2009 - Researchers have developed a novel animal model showing that four commonly used chemotherapy drugs disrupt the birth of new brain cells, and that the condition could be partially reversed with the gro...
http://www.bionity.com/news/e/111076/

Breakthrough drug for people intolerant of sunlight
12/22/2009 - A new pharmaceutical drug which protects people from sunlight may revolutionise preventative treatments for patients with a range of light-sensitive skin disorders. A 12 month trial of the drug, afame...
http://www.bionity.com/news/e/111148/

Umbilical cord could be new source of plentiful stem cells, say Pitt researchers
Banking cords, as well as cord blood, may be invaluable
12/22/2009 - Stem cells that could one day provide therapeutic options for muscle and bone disorders can be easily harvested from the tissue of the umbilical cord, just as the blood that goes through it provides p...
http://www.bionity.com/news/e/111077/

UCB announces initial clinical trial results involving patients taking certolizumab pegol for moderate to severe Crohn’s disease
12/22/2009 - UCB announced the preliminary results of a recently completed Phase IIIb, multinational, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of certolizumab pegol, a p...
http://www.bionity.com/news/e/111177/

EUR 400,000 for New Malaria Drug
12/22/2009 - The Bernhard Nocht Institute for Tropical Medicine (BNI) has received funds of EUR 400,000 from the City of Hamburg for the development of a new anti-malaria drug. In cooperation with the European Sc...
http://www.bionity.com/news/e/111142/

Researchers design a tool to induce controlled suicide in human cells
Scientists will use it to analyze the stress responses used by cells to solve genomic errors, and also to identify targets of therapeutic interest
12/21/2009 - When cells accumulate excessive errors in the proteins they produce, apoptosis is activated, that is to say, a cell suicide programme; however, beforehand the cells attempt to rectify the problem thro...
http://www.bionity.com/news/e/111074/

ThromboGenics Completes Patient Enrolment of Phase III Trial of Microplasmin for the Non-Surgical Treatment of Eye Disease
MIVI-TRUST Phase III Program With Microplasmin Recruits a Total of Over 640 patients Ahead of Schedule
12/21/2009 - ThromboGenics NV announced that it has completed the enrolment of the second Phase III trial evaluating microplasmin for the non-surgical treatment of eye disease. The trial TG-MV-007, which recruite...
http://www.bionity.com/news/e/111073/

Spectral Diagnostics enters into strategic collaboration with BioMS Medical to commercialize treatment for sepsis
12/21/2009 - Spectral Diagnostics Inc. and BioMS Medical Corp. announced that BioMS Medical and a syndicate of investors have invested $14 million in Spectral Diagnostics to advance Toraymyxin(TM), a treatment fo...
http://www.bionity.com/news/e/111069/

Within a cell, actin keeps things moving
University of Oregon-made technique is putting new light on machinery driving intracellular transport
12/21/2009 - Using new technology developed in his University of Oregon lab, chemist Andrew H. Marcus and his doctoral student Eric N. Senning have captured what they describe as well-orchestrated, actin-driven, m...
http://www.bionity.com/news/e/111075/

Merck Serono Announces Collaboration in Basic and Clinical Research in Multiple Sclerosis
12/21/2009 - Merck Serono, a division of Merck KGaA, announced a strategic collaboration with US ranked Brigham and Women's Hospital in Boston, to advance basic and clinical research in multiple sclerosis (MS), wi...
http://www.bionity.com/news/e/111068/

Argonne scientists use bacteria to power simple machines
Organisms turn microgears in suspended solution by swimming
12/18/2009 - Scientists at the U.S. Department of Energy’s (DOE) Argonne National Laboratory and Northwestern University, Evanston, have discovered that common bacteria can turn microgears when suspended in a sol...
http://www.bionity.com/news/e/111012/

Recipharm announces its intention to acquire Cobra Biomanufacturing
12/18/2009 - Recipharm AB announced its intention to acquire Cobra Biomanufacturing plc, a UK-based, cGMP compliant contract manufacturer of biopharmaceuticals. This move will considerably broaden Recipharm’s biol...
http://www.bionity.com/news/e/111014/

New Opportunities in Russian Pharma Market
Frost & Sullivan Comments on the Russian Health Ministry’s Plan to Enhance Domestic Production of Strategically Important Pharmaceuticals
12/18/2009 - The Russian Healthcare Development Program is likely to cause major structural changes in the Russian pharmaceutical market and create new opportunities for foreign investors. The main aim of the gove...
http://www.bionity.com/news/e/110990/

Clinuvel announces PLE Phase III preliminary results
Trial in polymorphic light eruption (PLE) to support the final registration dossier of afamelanotide
12/18/2009 - Clinuvel Pharmaceuticals Limited announced that it has obtained preliminary results in its multicenter randomised double-blind placebo controlled PLE study (CUV015) evaluating the safety and efficacy ...
http://www.bionity.com/news/e/111058/

Avantium appoints Gunnar Staaf as CEO Pharma
Strengthening of leadership team to prepare Pharma business for spin-out
12/18/2009 - Avantium announced the appointment of Gunnar Staaf as Chief Executive Officer of its pharmaceutical business. Gunnar Staaf previously worked at Serentis Ltd, Astellas Pharma, Novartis and Eli Lilly & ...
http://www.bionity.com/news/e/110987/

Septic shock: nitric oxide beneficial after all
12/17/2009 - Scientists at VIB and Ghent University have found an unexpected ally for the treatment of septic shock, the major cause of death in intensive care units. By inducing the release of nitric oxide (NO) g...
http://www.bionity.com/news/e/110959/

Biomodics triumphs at Eurecan European Venture Contest
12/17/2009 - Biomodics triumphed from 25 finalists from life sciences, ICT and cleantech in Barcelona, at the Eurecan European Venture Contest Final– winning €90,000 as the choice of an international jury of inves...
http://www.bionity.com/news/e/110958/

Intercell provides update on ongoing Phase II vaccine studies
Pseudomonas vaccine: Study in intensive care patients to investigate immunogenicity and safety of a Pseudomonas aeruginosa vaccine and to assess Pseudomonas infection rates
12/17/2009 - Intercell AG announced that interim data from a Phase II clinical trial investigating the compan's vaccine candidate for the prevention of infections with the bacterium Pseudomonas aeruginosa are ava...
http://www.bionity.com/news/e/110961/

Galapagos and GlaxoSmithKline broaden arthritis alliance
Expansion of programs based on promising drug target GT622 €6.5 M payment this year and additional milestones
12/17/2009 - Galapagos NV announced that it has expanded its arthritis alliance with GlaxoSmithKline to include additional drug discovery programs based on novel drug target GT622. Under the terms of this extensio...
http://www.bionity.com/news/e/110960/

Sequenom Appoints Two New Board Members
12/17/2009 - Sequenom, Inc. announced the appointment of Dr. Kenneth Buechler and Mr. David Pendarvis to its board of directors.
Kenneth F. Buechler, Ph.D., was president, chief scientific officer and co-found...
http://www.bionity.com/news/e/110985/

Scripps Research scientists crack mystery of protein's dual function
The work provides insight into potential therapeutic for cancer and eye diseases
12/16/2009 - Researchers at The Scripps Research Institute have solved a 10-year-old mystery of how a single protein from an ancient family of enzymes can have two completely distinct roles in the body. In additio...
http://www.bionity.com/news/e/110827/

QIAGEN Announces Closing of the Acquisition of SABiosciences
12/16/2009 - QIAGEN N.V. announced the completion of its previously announced acquisition of SABiosciences Corporation, a privately-held developer and manufacturer of disease- and pathway-focused PCR assay panels...
http://www.bionity.com/news/e/110870/

Ablynx initiates Phase I for ALX-0141
12/16/2009 - Ablynx announced that it has initiated a double-blind, randomised, placebo-controlled Phase I study with ALX-0141, a Nanobody® targeting Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), i...
http://www.bionity.com/news/e/110866/

Polyheal Announces Positive Clinical Results of its Lead Product, "Polyheal-1", for the Treatment of Chronic Wound Healing
12/16/2009 - Polyheal Ltd. announced positive clinical trial results of its lead product "Polyheal -1" for the treatment of deep and chronic wounds. The trial is a randomized double blind controlled comparing "Po...
http://www.bionity.com/news/e/110878/

Primary endpoint reached in Active Biotech's TASQ Phase II clinical trial in prostate cancer patients
12/16/2009 - A first analysis of the primary endpoint based on data from at least six months' treatment of more than 200 patients, has been performed in Active Biotech AB's ongoing Phase II clinical study of TASQ,...
http://www.bionity.com/news/e/110882/

Catalogues and Brochures

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TSK-GEL^® HILIC column brochure
Tosoh Bioscience presents a new brochure featuring the use of TSK-GEL HILIC columns. HILIC is the method of choice for the separation of very polar and hydrophilic compounds. Typical HILIC applications are the analysis of glycans, carbohydrates, peptides, polar drugs and metabolites, vitamins and other hydrophilic compounds...

http://www.bionity.com/catalogs/e/106318/

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Novodirect GmbH General Catalogue 2009
This catalogue features a wide selection of more than 35,000 products for industry and research. Please take notice of our sales...

http://www.bionity.com/catalogs/e/55408/

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Events

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Events, Workshops and Training Courses

Macromolecular characterisation by Field Flow Fractionation (AF4) and Multi Angle Light Scattering (MALS) - applications in pharmaceutical research
http://www.bionity.com/events/e/23842/

SPIE Medical Imaging 2010
http://www.bionity.com/events/e/22266/

31st Lorne Genome Conference on the Organization and Expression of the Genome
http://www.bionity.com/events/e/22984/

Project Management in Clinical Trials
http://www.bionity.com/events/e/23653/

POLYBUILD as part of RusBUILD
http://www.bionity.com/events/e/24337/

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